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Researchers Helped to Explore Microbiome space by microbiome Search Engine 2

Metagenomics, which is the study of genic material found from environmental samples, is experiencing growth as species are being discovered worldwide. Researchers from China have come up with a Microbiome Search Engine 2 (MSE 2) in order to match up the newly emerged microbiome with the current data. This was published in mSystems, an American Society Journal for Microbiology, on 19th January.

Jing Gongchao, co-first author Single-Cell Center and CAS Key Laboratory of Biofuels, said that he is glad that they are introducing a Microbiome Search Engine that will help examine microbiomes in the world metagenome data space depending on the operational similarity of the entire microbiome. Jing said that the search engine that was there before the limited examination to taxonomical similarities, which means matching up functional genes was a must. The researchers could not find any way to compare various samples that functioned the same in different microbiomes. If they could study how similar functions could have developed from multiple microbes, this could have provided direction to identify and treat different diseases.

The new capacity to search microbiome space through functional similarity is very crucial as it helps to enlarge the search-based mining’s scope of the microbiome big data. MSE 2 should speed off large-scale mining of the increasing metagenome data space through additional function-based dimensions for these and other associated applications.

MSE 2 comprises up-to-date data to help work to consolidate new data, a comprehensive database from 819 studies, and a user-friendly interface. It only takes less than half a second to search for a single query against the full database, which is over 260,000 samples.

Liu Lu, Single-Cell Center’s co-first author, said that they have been gathering published microbiome data over the last ten years. This means recording all microbe species’ kinds and microbial communities’ types that have ever survived on Earth. By gathering and organizing them into a lamentable database, MSE 2 enables future generations to remember these unseen but focal creatures that once lived on our planet. It will also give an opportunity for the scientists who discovered these creatures first to be acknowledged and appreciated.

The developers of MSE 2 are XU Jian from Single-Cell Center, QIBEBT, CAS, and SU Xiaoquan, who hails from the College of Computer and Technology, Qingdao University. Their work was supported by the Shandong Natural Science Foundation and the Natural Science Foundation of China.

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